KIR Polymorphism Workshop 2024
Preliminary Program
Monday May 6th
6:30 PM - 8:30 PM Dinner/Welcome reception
Tuesday May 7th
7:30 AM - 8:30 AM Breakfast
8:30 AM - 9:00 AM Welcome
Paul Norman
9:00 AM - 10:00 AM Introductory Speaker Justin Chuven
Innovations in the Journey to Recover the Black-footed Ferret
10:00 AM - 10:30 AM Mid-Morning Break
10:30 AM - 11:30 AM Session 1: KIR and Pregnancy
10:30 Ashley Moffett
Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy
10:45 Katherine Kichula
Genes encoding inhibitory KIR contribute to preecampsia risk in Uganda
11:00 Eric Long
An allosteric disulfide switch regulates ligand binding, endocytosis, and signaling by KIR2DL4 in NK cells
11:15 Sumi Rajagopalan
Soluble HLA-G activates a type I interferon response in primary human NK cells through KIR2DL4
11:30 AM - 12:45 PM Session 2: Basic Immunology
11:30 Malcom Sim
Activating KIR are not weak but peptide specific
11:45 Philippa Saunders
Variation in KIR3DL1 allotype binding to HLA ligands modifies the effects of education and detection of HLA loss
12:00 Stephen Anderson
Evaluation of functional polymorphisms in KIR2DL1 regulatory elements
12:15 Christelle Retiere
Multifactorial determinants of NK cell repertoire organization: Insights into age, sex, KIR genotype, HLA typing, and CMV influence
12:30 Laura Ann Leaton
Characterizing the role of KIR3DL3 in human intestine
12:45 PM - 2:00 PM Lunch
2:00 PM - 3:30 PM Session 3: Autoimmunity and Infectious Diseases
2:00 Jacqueline Williams
KIR2DL1*001/HLA-C2 is associated with risk for Multiple Sclerosis
2:15 Kerry Kizer
KIR3DL1*004 is Associated with Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS)
2:30 Randi Johnson
Killer Cell Immunoglobulin-like Receptor (KIR) Genetic Variation in the Natural History of Type 1 Diabetes
2:45 Andreas Kingsgaard
Interrogating TCR-dependent and KIR-affected HLA-C mediated CD8+ T-cell recognition in viral infections
3:00 Mary Carrington
KIR3DL1 interaction with variants of B57
3:15 Jeffrey Miller
Safety and virologic impact of haploidentical NK cells plus IL-2 or IL-15 in HIV infection and NK cell targeting of endogenous NK cells in vivo
3:30 PM - 4:00 PM Mid-afternoon Break
4:00 PM - 5:15 PM Session 4: Evolution, Function, and Structure
4:00 Jesse Bruijnesteijn
Elucidating the sequence features driving KIR diversification
4:15 Lisbeth Guethlein
Primate KIR haplotypes diversify by recombination and duplication.
4:30 Neus Font Porterias
Archaic human KIR3DL1 inhibits natural killer cells throughout First Nations Oceanians
4:45 Camilla Faoro
Structural basis to understand the differences in HLA-C recognition between activating and inhibitory KIR
5:00 Jan Peterson
Implications of activating KIR peptide-HLA specificity
6:30 PM - 8:30 PM Dinner/Reception
Wednesday May 8th
7:30 AM - 8:30 AM Breakfast
8:30 AM - 9:00 AM Session 5: Cancer and Transplantation
8:30 Enora Ferron
NK cells interactions with acute leukemia
8:45 Johanna Jansky
Cytotoxic function of KIR2DS1+ NK cells in HLA-C2 homozygous DLBCL patients and healthy donors
9:00 Sarah Cooley
Role of Activating KIR Gene Content on Ex-Vivo Expanded NK Cell Cytotoxicity
9:15 Salim Khakoo
Exportin-1 (XPO-1) as a target for KIR2DS2+ natural killer cells in hepatocellular carcinoma
9:30 Pilar Lanuza
Dual Blockade of KIR and NKG2A Receptors by tailored Antibodies with Improved Functional Properties
9:45 Antonia Schafer
High-resolution KIR genotyping and its implication in allogeneic hematopoietic stem cell transplantation
10:00 AM - 10:30 AM Mid-morning Break
10:30 AM - 11:15 AM Session 6: Cancer and Transplantation
10:30 Elizabeth Krieger
A Novel KIR-HLA Interaction Scoring System and its Effect on Transplantation Outcomes after HLA Matched Allogeneic Hematopoietic Stem Cell Transplantation
10:45 Stalinraja Maruthamuthu
Recipients with KIR2DL1 and HLA-C2C2, but donors lacking this ligand, correlate with superior kidney transplant outcomes.
11:00 Brendan Keating
MHC-KIR Association Studies in the International Genetics & Translational Research in Transplantation Network (iGeneTRAIN)
11:15 AM - 12:45 PM Session 7: Method Development 1
11:15 Abha Chopra
A high throughput method for allelic genotyping the KIR locus and its applications
11:30 Bram Luiken
Expansion on Whole Gene KIR genotyping strategies and testing on a commercially available human HLA variation reference panel
11:45 Ibrahim Numanagic
Geny: A Genotyping Tool for Allelic Decomposition of Killer Cell Immunoglobulin-Like Receptor Genes
12:00 Jonathan Downing
Long read sequencing of KIR genes
12:15 Ivan Wolf
An Integrated Pipeline for Analyzing Genomic Regions Encoding Natural Killer Cell Receptors
12:30 PM - 1:30 PM Lunch
1:30 PM - 2:30 PM Session 7: Method Development 2
1:30 Cynthia Vierra-Green
Complete KIR Haplotype Assignment of Eight Individuals from the NMDP Donor Registry
1:45 Qiandong Zeng
Utility of KIR Hybrid Probe Capture and Long Read Sequencing for Allele Typing and Phasing
2:00 Ying Zhou
Full resolution HLA and KIR genes annotation for human genome assemblies
2:15 Jason Chin
Pangenome Analysis of the KIR-Locus for 246 Haplotypes
2:30 PM - 3:30 PM Session 8: Population Genetics
2:30 Avik Bhattacharya
LILR full gene variation in European and African-American cohorts
2:45 Katia Gagne
High-resolution characterization of KIR genes in healthy French individuals
3:00 Juergen Sauter
Estimation of German KIR allele group haplotype frequencies
3:15 Noah Cline
KIR and HLA Diversity of Tsimane from Bolivia
3:30 PM - 3:45 PM Session 9: Nomenclature
3:30 Martin Maiers
KIR Haplotype Nomenclature: the Tower of Babel, the Cathedral and the Bazaar
3:45 PM - 6:00 PM Break
6:30 PM - 8:30 PM Dinner/Reception